Increased Vascular Permeability Induced by Human Plasmin
نویسنده
چکیده
Preparations of plasminogen, soluble in aqueous media, increased vascular permeability in guinea pig skin when activated by streptokinase or urokinase. The permeability-enhancing effect was inhibited by soybean trypsin inhibitor but not by triprolidine. Permeability-enhancing activity evolved when plasmin was incubated with fractions of plasma rich in prokinin. The experiments described suggest that plasmin exerts its permeability-increasing effect through the elaboration of kinins.
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عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 122 شماره
صفحات -
تاریخ انتشار 1965